Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Positron Emission Tomography

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Overview of treatment plan quality in a high dose rate prostate brachytherapy workflow.

Brachytherapy·2024

Same author

Application of a directional palladium-103 brachytherapy device on a curved surface.

Medical physics·2019

Same author

SU-E-T-590: Procedure for Verification and Inter-Comparison of IMRT Beam Models.

Medical physics·2017

Same author

SU-E-T-554: PTV to Skin Proximity for Head and Neck IMRT Treatment Planning.

Medical physics·2017

Same author

WE-G-BRB-01: Per-Frame Analysis of MatriXX Data.

Medical physics·2017

Same author

WE-G-BRB-09: CyberKnife Patient Specific QA Using a 4D Cylindrical Diode Array System.

Medical physics·2017

Search research articles

Related Experiment Video

Updated: Jun 23, 2026

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

Absolute dose reconstruction in proton therapy using PET imaging modality: feasibility study.

E Fourkal¹, J Fan, I Veltchev

¹Department of Radiation Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA, USA.

Physics in Medicine and Biology

|May 14, 2009

Summary

This study presents a novel analytical model for precise proton beam radiation dose reconstruction using PET imaging. The method accurately recovers the delivered dose within 2% by deconvoluting PET signals with a calculated positron emitters

More Related Videos

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy (PRRT): 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy (PRRT): 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods

Published on: April 24, 2020

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Related Experiment Videos

Last Updated: Jun 23, 2026

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy (PRRT): 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy (PRRT): 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods

Published on: April 24, 2020

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Area of Science:

Medical Physics
Radiotherapy Physics
Nuclear Medicine

Background:

Accurate dose reconstruction is crucial for effective proton beam therapy.
Positron Emission Tomography (PET) offers 3D imaging capabilities post-treatment.
Current methods for dose recovery from PET data can be complex and computationally intensive.

Purpose of the Study:

To develop a simple analytical model for efficient absolute dose reconstruction in proton therapy.
To enable dose recovery from 3D PET signals acquired immediately after treatment.
To validate the model's accuracy in dose reconstruction.

Main Methods:

Developed an analytical model based on solving the inverse problem of dose recovery.
Introduced the concept of a positron emitters' species matrix (PESM) or kernel.
Utilized theoretical calculations of proton energy fluence distribution to derive the PESM.
Employed deconvolution of 3D PET activity distribution with the PESM for dose reconstruction.
Validated the model using FLUKA Monte Carlo simulations on a tissue phantom.

Main Results:

The analytical model allows for efficient absolute dose reconstruction.
The core of the model involves the analytical calculation of the PESM.
Deconvolution of simulated PET activity with the PESM yielded reconstructed doses within 2% of the delivered dose.
Demonstrated the model's effectiveness in a simulated parallel-opposed proton beam arrangement.

Conclusions:

The developed analytical model provides an efficient and accurate method for absolute dose reconstruction in proton therapy.
This approach leverages PET imaging for immediate post-treatment dose verification.
The PESM-based deconvolution technique offers a promising tool for quality assurance in radiation oncology.