Recent developments of the quantum chemical cluster approach for modeling enzyme reactions

Per E M Siegbahn1, Fahmi Himo

  • 1Department of Physics, ALBA NOVA, Arrhenius Laboratory, Stockholm University, Stockholm, Sweden. ps@physto.se

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For many years, scientists thought that enzyme-substrate binding took place in a simple "lock-and-key" fashion. This model stated that the enzyme and substrate fit together perfectly in one instantaneous step. However, current research supports a more refined view scientists call induced fit. The induced-fit model expands upon the lock-and-key model by describing a more dynamic interaction between enzyme and substrate. As the enzyme and substrate come together, their interaction causes a mild...
Introduction to Mechanisms of Enzyme Catalysis01:13

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