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Related Experiment Video

Updated: Jun 23, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Scleroderma (systemic sclerosis) among Nigerians.

O O Adelowo1, S Oguntona

  • 1Rheumatology Unit, Department of Medicine, Olabisi Onabanjo University Teaching Hospital, Sagamu, Ogun State, Nigeria. femiadelowo2003@yahoo.com

Clinical Rheumatology
|May 14, 2009
PubMed
Summary

Scleroderma is rare in Africans, with this study in Nigeria showing mostly female patients with diffuse disease. Common symptoms included arthritis and reflux, with lung function abnormalities also noted.

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Last Updated: Jun 23, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Area of Science:

  • Rheumatology
  • Dermatology
  • Immunology

Background:

  • Scleroderma, a rare connective tissue disease, has limited reported cases among African populations.
  • This study aimed to characterize scleroderma in a Nigerian rheumatology clinic.

Observation:

  • A retrospective review identified 14 scleroderma cases.
  • The majority of patients were female, with diffuse scleroderma being more prevalent.
  • Common presentations included arthritis and reflux esophagitis; Raynaud's phenomenon and dysphagia were least common.

Findings:

  • Pulmonary function tests revealed restrictive patterns in most patients, with some exhibiting pulmonary fibrosis.
  • Antinuclear antibodies (ANA) with a speckled pattern were the most frequent serological findings.
  • Standard medications were used for treatment.

Implications:

  • Scleroderma in Nigerians shares similarities with global patterns but also presents unique characteristics.
  • Further research is needed to understand the specific epidemiology and clinical spectrum of scleroderma in African populations.
  • This study highlights the importance of recognizing scleroderma in diverse ethnic groups.