Related Experiment Video

Updated: Jun 23, 2026

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas
05:31

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas

Published on: January 26, 2024

CA-125 and CRP are elevated in preeclampsia

Fatma Bahar Cebesoy1, Ozcan Balat, Ebru Dikensoy

  • 1Obstetric and Gynecology Department, Gaziantep University Faculty of Medicine, Gaziantep/Turkey. fbcebesoy@yahoo.com

Hypertension in Pregnancy
|May 14, 2009
PubMed

Insights

C-reactive protein (CRP) and cancer antigen-125 (CA-125) are elevated in preeclampsia and eclampsia. These markers correlate with disease severity, indicating their role in monitoring preeclampsia.

Area of Science:

  • Obstetrics and Gynecology
  • Clinical Chemistry
  • Immunology

Background:

  • Preeclampsia and eclampsia are severe pregnancy complications.
  • Biomarkers for early detection and severity assessment are crucial.

Purpose of the Study:

  • To investigate the relationship between C-reactive protein (CRP) and cancer antigen-125 (CA-125) levels and the presence and severity of preeclampsia and eclampsia.

Main Methods:

  • A case-control study involving 54 women with preeclampsia/eclampsia and 56 healthy pregnant controls.
  • Measurement of CRP and CA-125 levels, along with mean arterial pressure (MAP) and albumin levels.
  • Statistical analysis using t-test, Pearson correlation, and ANOVA.

Main Results:

  • CRP and CA-125 levels were significantly higher in women with preeclampsia/eclampsia compared to controls (p < 0.001).
  • Elevated levels of both markers were observed in severe preeclampsia and eclampsia compared to mild preeclampsia (p < 0.001).
  • Significant correlations were found between CRP and CA-125 with MAP and albumin levels (p < 0.001).

Conclusions:

  • CRP and CA-125 serve as significant elevating markers in preeclampsia.
  • These markers show potential for monitoring disease severity in preeclamptic and eclamptic conditions.
Abstract

More Related Videos

A Plate-based Cytotoxicity Assay for the Assessment of Rat Placental Natural Killer Cell Cytolytic Function10:44

A Plate-based Cytotoxicity Assay for the Assessment of Rat Placental Natural Killer Cell Cytolytic Function

Published on: June 2, 2019

Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Hormonal Regulation01:33

Hormonal Regulation

The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
Measurement of Blood Pressure01:17

Measurement of Blood Pressure

Assessing blood pressure is a standard procedure executed in virtually all medical environments. The method utilized today was established over a hundred years ago by an innovative Russian doctor, Dr. Nikolai Korotkoff. The soft ticking noise, known as Korotkoff sounds, heard while taking blood pressure readings results from turbulent blood flow within the vessels. The apparatus required for this procedure includes a sphygmomanometer, a blood pressure cuff attached to a gauge, and a stethoscope.
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...