Related Experiment Video
Updated: Jun 23, 2026
Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas
Published on: January 26, 2024
Cytokines profiles in Sudanese women with preeclampsia
Khalid H Bakheit1, Nada K Bayoumi, Ahmed M Eltom
1Faculty of Medicine, University of Khartoum, Sudan.
Background:
Cytokine imbalance in preeclampsia may be one of the etiological factors for preeclampsia.
Objectives:
The study was conducted to investigate interferon gamma (IFN-gamma), interleukin-4 (IL-4) and interleukin-10 (IL-10) in preeclampsia. Enzyme-linked immunosorbent assay (ELISA) was used to measure the concentrations of these three pro-inflammatory cytokines in sera from 33 Sudanese women with preeclampsia (at presentation and 7 days later) and 32 women with normal pregnancy as a control group.
Results:
The levels of IFN-gamma and IL-4 were slightly--not statistically significant--higher in the women with preeclampsia. IL-10 was significantly higher in the women with preeclampsia. Women with preeclampsia had significantly lower levels of IFN-gamma and IL-4 and significantly higher levels of IL-10 7 days later in comparison with the presenting levels.
Conclusion:
Thus, the significantly raised levels of IL-10 in women with preeclampsia suggest its role in pathogenesis of preeclampsia, and further research is needed.
Related Concept Videos
01:33Hormonal Regulation
01:24Chronic Kidney Disease II: Clinical Manifestations