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Diffusion weighted image (DWI) findings in methanol intoxication

Humera Ahsan1, Muhammad Akbar, Aamir Hameed

  • 1Radiology Department, Aga Khan University Hospital, Karachi.

JPMA. the Journal of the Pakistan Medical Association
|May 15, 2009
PubMed

Insights

Methanol poisoning can cause severe brain damage, specifically necrosis in the putamen areas. Diffusion-weighted imaging revealed additional, previously unseen, frontal and occipital lobe lesions.

Area of Science:

  • Neuroscience
  • Toxicology
  • Radiology

Background:

  • Methanol is a highly toxic industrial solvent.
  • Exposure can lead to severe neurological deficits and mortality.
  • Prompt diagnosis and understanding of toxic effects are crucial.

Observation:

  • A case of acute methanol poisoning is presented.
  • Magnetic Resonance Imaging (MRI) of the brain was performed.
  • Diffusion-weighted imaging (DWI) was utilized for detailed lesion characterization.

Findings:

  • MRI revealed bilateral putaminal necrosis, a characteristic sign of methanol toxicity.
  • DWI demonstrated abnormal signals and diffusion-positive lesions in the putamen.
  • Additional bilateral lesions in the frontal and occipital lobes were identified on DWI, not visible on conventional MRI sequences.

Implications:

  • Highlights the diagnostic utility of DWI in detecting early ischemic changes in toxic encephalopathies.
  • Emphasizes the severe neurotoxic potential of methanol.
  • Underscores the importance of advanced neuroimaging in managing poisoning cases.

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