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Related Concept Videos

Tension01:10

Tension

Tension is a force along the length of a medium, in particular, a force carried by a flexible medium, such as a rope or cable. The word "tension" comes from Latin, meaning "to stretch". Not coincidentally, the flexible cords that carry muscle forces to other parts of the body are called tendons. Any flexible connector, such as a string, rope, chain, wire, or cable, can exert pull only parallel to its length; so, a force carried by a flexible connector is a tension with a direction parallel to...
Tension01:10

Tension

Tension is a force along the length of a medium, in particular, a force carried by a flexible medium, such as a rope or cable. The word "tension" comes from Latin, meaning "to stretch". Not coincidentally, the flexible cords that carry muscle forces to other parts of the body are called tendons. Any flexible connector, such as a string, rope, chain, wire, or cable, can exert pull only parallel to its length; so, a force carried by a flexible connector is a tension with a direction parallel to...
Principal Stresses01:24

Principal Stresses

The graphical depiction of normal and shearing stress equations is represented by a circle, demonstrating the interplay between these stresses under different angular conditions. The center of this circle C, located on the vertical axis, represents the average normal stress, while its radius shows the range of stress variations. At points A and B, where the circle intersects the horizontal axis, the maximum and minimum normal stresses are observed, occurring without shearing stress. These...
Stress-Strain Diagram01:10

Stress-Strain Diagram

A stress-strain diagram is a crucial tool that graphically displays a material's mechanical characteristics. This diagram is derived from a tensile test performed on a carefully prepared cylindrical specimen. The specimen has two gauge marks inscribed on its central part, and the distance between these marks is known as the gauge length. The cylindrical specimen is placed in a testing machine, which applies an increasing centric load. As this load grows, so does the gauge length. This change in...
Stress Concentrations in Circular Shafts01:18

Stress Concentrations in Circular Shafts

Consider the elastic torsion formula, which applies to a circular shaft with a consistent cross-section. This formula assumes that the shaft's ends are loaded with rigid plates firmly attached. However, in many cases, torques are applied to the shaft through mechanisms like flange couplings or gears, which are connected by keys inserted into keyways. This application method modifies the stress distribution near the point of torque application, causing it to deviate from the distributions...
Tension Response at Adherens Junctions01:26

Tension Response at Adherens Junctions

The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
α-Catenin as a Mechanosensory Protein
The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin homology) domains...

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Tension Gauge Tether Probes for Quantifying Growth Factor Mediated Integrin Mechanics and Adhesion
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Company profile: tengion.

Timothy Bertram

    Regenerative Medicine
    |May 15, 2009
    PubMed
    Summary

    Tengion pioneers organ regeneration using a patient's own cells and biocompatible materials. This approach aims to restore organ function, potentially eliminating the need for transplants and their associated side effects.

    Area of Science:

    • Regenerative Medicine
    • Biotechnology
    • Tissue Engineering

    Background:

    • Tengion is a clinical-stage company focused on organ regeneration.
    • The company utilizes a proprietary Autologous Organ Regeneration Platform.

    Discussion:

    • The platform employs biocompatible materials and autologous cells to create neo-organs and neo-tissues.
    • This method is designed to stimulate the body's natural regenerative capabilities.

    Key Insights:

    • Tengion's technology addresses critical issues in organ and tissue failure.
    • The company has integrated manufacturing and R&D capabilities in the US and Europe.
    • Significant intellectual property supports their regenerative therapies.

    Outlook:

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    • Product candidates target urologic, vascular, and renal regeneration.
    • The goal is to enable healthier lives for patients without donor transplants.
    • Potential to mitigate side effects associated with current transplant therapies.