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Published on: April 7, 2014
Cardiovascular effects of Org OD 14--a new steroidal therapy for climacteric symptoms
P Hardiman1, P Nihoyannopoulos, P Kicovic
1Department of Endocrinology, Royal Free Hospital, London, U.K.
Abstract:
The cardiovascular effects of Org OD 14, a synthetic steroid which relieves climacteric symptoms without stimulating the endometrium, were assessed in a group of healthy post-menopausal women. Limb blood flow was measured by venous occlusion plethysmography. Resting forearm blood flow, the dilator response to anoxic exercise and heart rate increased significantly after six weeks of drug treatment. Hand flow was unchanged. The cardiovascular effects of Org OD 14 differ from those seen with oestrogens, in keeping with the unique pharmacological profile of this steroid.
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