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Related Concept Videos

Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...

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Updated: Jun 23, 2026

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
17:28

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation

Published on: June 17, 2015

Human embryonic stem cells as a model for embryotoxicity screening.

Ana Krtolica1, Dusko Ilic, Olga Genbacev

  • 1SLL Sciences, StemLifeLine, Inc., San Carlos, CA, USA.

Regenerative Medicine
|May 15, 2009
PubMed
Summary

Human embryonic stem cells (hESCs) offer superior in vitro models for studying pre-implantation embryotoxicity compared to mouse models. These hESC-based systems can assess early human embryo development and toxicity screening.

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Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells
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Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells

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Robust Generation of Hepatocyte-like Cells from Human Embryonic Stem Cell Populations
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Robust Generation of Hepatocyte-like Cells from Human Embryonic Stem Cell Populations

Published on: October 26, 2011

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Last Updated: Jun 23, 2026

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
17:28

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Published on: June 17, 2015

Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells
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Robust Generation of Hepatocyte-like Cells from Human Embryonic Stem Cell Populations
05:49

Robust Generation of Hepatocyte-like Cells from Human Embryonic Stem Cell Populations

Published on: October 26, 2011

Area of Science:

  • Reproductive toxicology
  • Developmental biology
  • Stem cell research

Background:

  • Reproductive toxicity affects fertility and early development.
  • Pre-implantation embryotoxicity is critical but poorly understood.
  • Environmental factors significantly impact early embryo development.

Purpose of the Study:

  • To review models for pre-implantation embryotoxicity screening.
  • To highlight the advantages of human embryonic stem cells (hESCs) over mouse models.
  • To discuss current hESC-based systems for modeling early human embryonic development.

Main Methods:

  • Focus on modeling pre-implantation embryotoxicity using hESCs.
  • Review of hESC-based systems for trophectoderm differentiation and inner cell mass segregation.
  • Comparison of human and mouse pre-implantation development and stem cells.

Main Results:

  • hESCs and their derivatives are better suited for modeling human pre-implantation development than mouse models.
  • Existing hESC systems can model key early differentiation events.
  • These models show potential for future embryo toxicity screening.

Conclusions:

  • hESC-based models are promising for assessing pre-implantation embryotoxicity.
  • Further improvements can enhance the utility of these models in toxicology.
  • Understanding environmental influences on early development is crucial for addressing infertility.