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Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Disorders of Leukocytes01:27

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...

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Related Experiment Video

Updated: Jun 23, 2026

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation
07:17

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation

Published on: August 23, 2024

Highly increased familial risks for specific lymphoma subtypes.

Lynn R Goldin1, Magnus Björkholm, Sigurdur Y Kristinsson

  • 1Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892-7236, USA. goldinl@mail.nih.gov

British Journal of Haematology
|May 15, 2009
PubMed
Summary
This summary is machine-generated.

Familial risk significantly increases the likelihood of developing specific lymphoma subtypes. First-degree relatives of patients with follicular lymphoma (FL), diffuse large B-cell lymphoma (DLBCL), and Hodgkin lymphoma (HL) showed elevated risks for the same cancer.

Related Experiment Videos

Last Updated: Jun 23, 2026

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation
07:17

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation

Published on: August 23, 2024

Area of Science:

  • Oncology
  • Genetics
  • Epidemiology

Background:

  • Familial risk is a known factor in the etiology of lymphomas.
  • Understanding the genetic basis of lymphoma subtypes is crucial for risk assessment and prevention strategies.

Purpose of the Study:

  • To evaluate the risk of specific lymphoma subtypes among first-degree relatives of patients diagnosed with follicular lymphoma (FL), diffuse large B-cell lymphoma (DLBCL), and Hodgkin lymphoma (HL).
  • To investigate whether familial risk for lymphoma is specific to the subtype.

Main Methods:

  • Utilized large population registries from Sweden.
  • Compared lymphoma subtype risk in first-degree relatives of 2668 FL, 2517 DLBCL, and 6963 HL patients against first-degree relatives of controls.

Main Results:

  • First-degree relatives had the highest risk of developing the same lymphoma subtype as the index patient.
  • Risk for diffuse large B-cell lymphoma (DLBCL) was increased 10-fold in relatives of DLBCL patients.
  • Risk for follicular lymphoma (FL) and Hodgkin lymphoma (HL) was increased fourfold in relatives of patients with the respective subtypes.

Conclusions:

  • Germline susceptibility genes appear to be specific to lymphoma subtype.
  • These findings highlight the importance of family history in assessing lymphoma risk.