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Related Concept Videos

Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
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Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
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Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
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Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Atypical Pneumonia

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Related Experiment Video

Updated: Jun 23, 2026

Intraductal Injection of LPS as a Mouse Model of Mastitis: Signaling Visualized via an NF-κB Reporter Transgenic
08:51

Intraductal Injection of LPS as a Mouse Model of Mastitis: Signaling Visualized via an NF-κB Reporter Transgenic

Published on: September 4, 2012

Cutaneous actinomycosis presenting as chronic mastitis.

F Al-Niaimi1, A Patel, K Blessing

  • 1Alan Lyell Department of Dermatology, Western Infirmary, Glasgow, UK. firas55@hotmail.com

Clinical and Experimental Dermatology
|May 15, 2009
PubMed
Summary

Actinomycosis, a rare cutaneous infection, can mimic chronic mastitis. Prompt diagnosis via skin biopsy and prolonged clindamycin treatment are crucial for effective management of this challenging condition.

Related Experiment Videos

Last Updated: Jun 23, 2026

Intraductal Injection of LPS as a Mouse Model of Mastitis: Signaling Visualized via an NF-κB Reporter Transgenic
08:51

Intraductal Injection of LPS as a Mouse Model of Mastitis: Signaling Visualized via an NF-κB Reporter Transgenic

Published on: September 4, 2012

Area of Science:

  • Infectious Diseases
  • Dermatology

Background:

  • Actinomycosis is a chronic granulomatous infection caused by anaerobic Actinomyces bacteria.
  • Primary cutaneous actinomycosis is rare due to the organism's endogenous habitat.

Observation:

  • A 35-year-old woman presented with symptoms mimicking chronic mastitis post-partum.
  • Initial antibiotic treatments for mastitis were ineffective.

Findings:

  • Skin biopsy revealed characteristic 'sulphur granules' indicative of actinomycosis.
  • Long-term oral clindamycin therapy (>12 months) resulted in significant clinical improvement and reduced inflammatory markers.

Implications:

  • This case highlights an unusual presentation of cutaneous actinomycosis.
  • Histological diagnosis using 'sulphur granules' is key when cultures are negative.
  • Prolonged antibiotic courses are necessary for successful treatment of cutaneous actinomycosis.