Related Experiment Video

Updated: Jun 23, 2026

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
09:32

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Published on: September 26, 2019

Risk factors for severe impetiginized atopic dermatitis in Japan and assessment of its microbiological features

K Hayakawa1, K Hirahara, T Fukuda

  • 1Department of Dermatology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan. haykaz@kyorin-u.ac.jp

Clinical and Experimental Dermatology
|May 15, 2009
PubMed

Insights

Poorly controlled atopic dermatitis (AD) in adults increases the risk of severe impetiginized AD. This condition often involves co-infections with Streptococcus pyogenes and Staphylococcus aureus, with S. pyogenes potentially driving severe symptoms.

Area of Science:

  • Dermatology
  • Infectious Diseases
  • Microbiology

Background:

  • Patients with atopic dermatitis (AD) are prone to bacterial skin infections.
  • Severe impetiginized AD can present with extensive dermatitis and high fever in AD patients.

Purpose of the Study:

  • To identify risk factors for severe impetiginized AD.
  • To characterize the microbiological features of severe impetiginized AD.

Main Methods:

  • Retrospective review of clinical and microbiological data.
  • Analysis of 14 adult patients with impetiginized AD admitted between 1999-2006.
  • Lesional skin cultures to identify bacterial pathogens.

Main Results:

  • All 14 patients had poorly controlled AD with widespread eczematous lesions.
  • The mean age of patients was 28.2 years.
  • Co-infection with Streptococcus pyogenes and Staphylococcus aureus was found in 12 patients; S. pyogenes alone in 2.

Conclusions:

  • Poorly controlled adult atopic dermatitis is a significant risk factor for severe impetiginization.
  • Streptococcus pyogenes may play a crucial role in the development of severe clinical symptoms in impetiginized AD.
  • Co-infection with S. pyogenes and S. aureus is common in severe impetiginized AD.

More Related Videos

Murine Model of Epicutaneously-Induced Immunomodulation09:07

Murine Model of Epicutaneously-Induced Immunomodulation

Published on: June 24, 2025

Related Concept Videos

Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
The Skin Microbiota01:27

The Skin Microbiota

The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...