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Composite Scaffolds of Interfacial Polyelectrolyte Fibers for Temporally Controlled Release of Biomolecules
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Temporary polysaccharide dermal fillers: a model for persistence based on physical properties.

Samuel J Falcone1, Richard A Berg

  • 1FzioMed Inc, San Luis Obispo, CA 93401, USA.

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [Et Al.]
|May 15, 2009
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Summary

Understanding dermal filler properties is key for better designs. This study found that polymer concentration and tan delta predict the clinical persistence of polysaccharide fillers like hyaluronic acid and CMC/PEO.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Dermatology

Background:

  • The physical and chemical properties influencing temporary dermal filler longevity remain unclear.
  • Identifying these properties can guide the development of advanced, long-lasting dermal fillers.

Purpose of the Study:

  • To investigate the rheology of polysaccharide dermal fillers.
  • To develop a predictive model for the clinical persistence of these fillers based on rheological data.

Main Methods:

  • Commercial cross-linked hyaluronic acid (XLHA) fillers and an in-house sodium carboxymethylcellulose (CMC) and polyethylene oxide (PEO) filler were analyzed.
  • Rheologic properties were measured and correlated with clinical persistence data from studies.

Main Results:

  • A linear correlation was observed between dermal filler clinical persistence and the ratio of polymer concentration to tan delta (G''/G').

Conclusions:

  • A predictive model utilizing polysaccharide concentration and formulation tan delta accurately forecasts the clinical persistence of XLHA and CMC/PEO dermal fillers.