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Published on: September 5, 2017
Differential long-term stimulation of type I versus type III collagen after infrared irradiation
Yohei Tanaka1, Kiyoshi Matsuo, Shunsuke Yuzuriha
1Department of Plastic and Reconstructive Surgery, School of Medicine, Shinshu University, Matsumoto, Japan. info@clinicatanaka.jp
Background:
The dermis is composed primarily of type I (soft) and type III (rigid scar-like) collagen. Collagen degradation is considered the primary cause of skin aging. Studies have proved the efficacy of infrared irradiation on collagen stimulation but have not investigated the differential long-term effects of infrared irradiation on type I and type III collagen.
Objective:
To determine differential long-term stimulation of type I and type III collagen after infrared (1,100-1,800 nm) irradiation.
Methods And Materials:
In vivo rat tissue was irradiated using the infrared device. Histology samples were analyzed for type I and III collagen stimulation, visual changes from baseline, and treatment safety up to 90 days post-treatment.
Results:
Infrared irradiation provided long-term stimulation of type I collagen and temporary stimulation of type III collagen. Treatment also created long-term smoothing of the epidermis, with no observed complications.
Conclusions:
Infrared irradiation provides safe, consistent, long-term stimulation of type I collagen but only short-term stimulation in the more rigid type III collagen. This is preferential for cosmetic patients looking for improvement in laxity and wrinkles while seeking smoother, more youthful skin.
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