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Published on: October 28, 2020

Assessment of left ventricular systolic synchronization in patients with chronic kidney disease and narrow QRS

Omer Gedikli1, Merih Baykan, Kubra Kaynar

  • 1KTU Faculty of Medicine, Department of Cardiology, Trabzon, Turkey. omergedikli@yahoo.com

Echocardiography (Mount Kisco, N.Y.)
|May 15, 2009
PubMed

Insights

Left ventricular (LV) systolic asynchrony is more prevalent in chronic kidney disease (CKD) patients with normal QRS duration. This cardiac abnormality may develop in CKD, impacting heart function.

Area of Science:

  • Cardiology
  • Nephrology
  • Medical Imaging

Background:

  • Chronic kidney disease (CKD) is associated with cardiac abnormalities.
  • Echocardiography has previously demonstrated structural and functional cardiac changes in CKD patients.
  • The presence of left ventricular (LV) asynchrony in CKD patients with normal QRS duration remains under investigation.

Purpose of the Study:

  • To investigate the presence of LV asynchrony in patients with CKD and normal QRS duration.
  • To assess whether LV systolic asynchrony is a feature of CKD independent of QRS duration.

Main Methods:

  • Tissue synchronization imaging (TSI) was employed in 25 CKD patients and 25 controls.
  • LV asynchrony was identified using TSI, measuring time to regional peak systolic velocity (Ts).
  • Four TSI parameters of systolic asynchrony were computed using a six-basal-six-midsegmental LV model.

Main Results:

  • Patients with CKD exhibited significantly prolonged Ts parameters compared to controls (P < 0.01 for all).
  • The prevalence of LV systolic asynchrony was significantly higher in CKD patients (44%) versus controls (12%) (P = 0.01).
  • LV asynchrony parameters were associated with LV dimensions, mass, blood pressure, and renal function in univariate analysis.

Conclusions:

  • LV systolic asynchrony may develop in patients with CKD.
  • These findings suggest a potential mechanism for cardiac dysfunction in CKD beyond traditional markers.
Abstract

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