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Responses in children to measles vaccination associated with perirenal transplantation
Kazuetsu Mori1, Ken Kawamura, Masataka Honda
1Seirei Sakura Citizen Hospital, Saitama Medical University, Saitama, Japan. kazuetsu@sis.seirei.or.jp
Insights
Live measles vaccination is safe and effective for children with chronic renal failure. The study found high seroconversion rates and antibody maintenance comparable to healthy children, indicating robust protection against measles.
Area of Science:
- Pediatric Nephrology
- Immunology
- Vaccinology
Background:
- Measles infection poses a significant mortality risk to immunosuppressed pediatric patients with chronic renal failure or post-renal transplantation.
- Assessing the efficacy of live measles vaccination is crucial for this vulnerable population.
Purpose of the Study:
- To evaluate the safety and immunogenicity of a single live measles vaccination in children with chronic renal failure.
- To determine seroconversion rates, antibody maintenance, and antibody titer elevation post-vaccination.
Main Methods:
- Investigated antibody titers before and after transplantation in 156 children with renal failure.
- Administered live measles vaccine to 42 children with negative antibody titers.
- Monitored seroconversion rate, antibody maintenance, and titer elevation.
Main Results:
- Achieved a high seroconversion rate of 97.6% following measles vaccination.
- Observed significant antibody titers (HI: 72 ± 118 fold; EIA: 36.9 ± 31.3).
- Reported no adverse side-effects associated with the vaccination in any participants.
Conclusions:
- Live measles vaccination is a safe and effective strategy for children with chronic renal failure.
- Immunological response (seroconversion, maintenance, and elevation) to measles vaccination is comparable to healthy children.
- Vaccination provides essential protection against measles in this immunocompromised pediatric group.
Background:
Measles infection can be fatal in pediatric patients with chronic renal failure or in patients who have undergone renal transplantation, both of whom are in the immunosuppressed state. The efficacy of single, live measles vaccination in preventing infection was examined.
Methods:
Of 156 children with renal failure who underwent renal transplantation, the changes in antibody titer were investigated before and after renal transplantation in 125 children whose measles antibody titer could be examined, together with disease and vaccination histories. Live measles vaccine was administered to 42 children with negative antibody titer. The antibody seroconversion rate was then investigated in these children, along with rate of antibody maintenance and degree of antibody titer elevation.
Results:
Seroconversion rate was 97.6%. Antibody titers measured on HI and EIA were 72 +/- 118 fold (HI) and 36.9 +/- 31.3 (EIA), respectively. The geometric mean of the increase in antibody titer 6 months after vaccination was 15. No side-effects of vaccination were observed in any of the children.
Conclusions:
Live measles vaccination of children with chronic renal failure is effective and safe, because the seroconversion rate, rate of antibody titer maintenance and degree of antibody titer elevation in children with chronic renal failure were all equivalent to those of healthy children.
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