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Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

Lichen planus and dyslipidaemia: a case-control study.

J Dreiher¹, J Shapiro, A D Cohen

¹Hospitals Division, Clalit Health Services, Tel Aviv, Israel. jacod@bgu.ac.il

The British Journal of Dermatology

|May 15, 2009

Summary

Lichen planus (LP) is linked to higher rates of dyslipidaemia, a condition affecting blood lipid levels. This study confirms the association in Israel, highlighting a potential health concern for LP patients.

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Last Updated: Jun 23, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

Area of Science:

Dermatology
Cardiovascular Health
Epidemiology

Background:

Psoriasis, a chronic inflammatory skin condition, has been previously linked to dyslipidaemia.
Lichen planus (LP) is another chronic inflammatory disorder with potential systemic implications.

Purpose of the Study:

To investigate the association between lichen planus (LP) and dyslipidaemia in the Israeli population.
To determine if LP is an independent risk factor for dyslipidaemia.

Main Methods:

A case-control study was conducted using data from Clalit Health Services in Israel.
1477 patients diagnosed with LP were compared to 2856 controls without LP.
Data on lifestyle factors and comorbidities were collected and analyzed.

Main Results:

The prevalence of dyslipidaemia was significantly higher in patients with LP (42.5%) compared to controls (37.8%).
LP remained significantly associated with dyslipidaemia after adjusting for confounders (multivariate OR 1.34).
The association was statistically significant (P < 0.001).

Conclusions:

Lichen planus (LP) is significantly associated with dyslipidaemia.
This finding suggests a potential link between chronic inflammatory skin conditions and lipid metabolism disorders.