Related Experiment Video
Updated: Jun 23, 2026
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Effect of systemic monosodium glutamate (MSG) on headache and pericranial muscle sensitivity
L Baad-Hansen1, Be Cairns, M Ernberg
1Department of Clinical Oral Physiology, School of Dentistry, University of Aarhus, Aarhus, Denmark. lbhansen@odont.au.dk
Abstract:
We conducted a double-blinded, placebo-controlled, crossover study to investigate the occurrence of adverse effects such as headache as well as pain and mechanical sensitivity in pericranial muscles after oral administration of monosodium glutamate (MSG). In three sessions, 14 healthy men drank sugar-free soda that contained either MSG (75 or 150 mg/kg) or NaCl (24 mg/kg, placebo). Plasma glutamate level, pain, pressure pain thresholds and tolerance levels, blood pressure (BP), heart rate and reported adverse effects were assessed for 2 h. No muscle pain or robust changes in mechanical sensitivity were detected, but there was a significant increase in reports of headache and subjectively reported pericranial muscle tenderness after MSG. Systolic BP was elevated in the high MSG session compared with low MSG and placebo. These findings add new information to the concept of MSG headache and craniofacial pain sensitivity.
Insights
Monosodium glutamate (MSG) intake can trigger headaches and pericranial muscle tenderness in some individuals. This study found MSG increased headache reports and elevated systolic blood pressure, but not muscle pain.
Area of Science:
- Neuroscience
- Gastroenterology
- Clinical Pharmacology
Background:
- Monosodium glutamate (MSG) is a common food additive with a controversial history regarding its potential adverse effects.
- Previous research suggests a link between MSG consumption and adverse reactions, including headaches, though mechanisms remain debated.
Purpose of the Study:
- To investigate the effects of oral monosodium glutamate (MSG) administration on headache occurrence and pericranial muscle sensitivity.
- To assess changes in pain thresholds, blood pressure, and heart rate following MSG intake.
Main Methods:
- A double-blinded, placebo-controlled, crossover study involving 14 healthy male participants.
- Participants consumed sugar-free soda containing either MSG (75 or 150 mg/kg) or a placebo (NaCl).
- Assessed plasma glutamate levels, pain, pressure pain thresholds, blood pressure, heart rate, and adverse effects for 2 hours post-ingestion.
Main Results:
- MSG consumption led to a significant increase in reported headaches and subjective pericranial muscle tenderness.
- No significant muscle pain or changes in mechanical sensitivity were observed.
- Systolic blood pressure was elevated in the high MSG dose session compared to low MSG and placebo sessions.
Conclusions:
- Oral MSG administration can induce headaches and pericranial muscle tenderness in susceptible individuals.
- MSG may influence cardiovascular parameters, indicated by elevated systolic blood pressure.
- Findings contribute to understanding the pathophysiology of MSG-related headaches and craniofacial pain sensitivity.
