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Updated: Jun 23, 2026

Large-Scale Multi-Omics Genome-Wide Association Studies (Mo-GWAS): Guidelines for Sample Preparation and Normalization
Published on: July 27, 2021
Genome-wide association studies in pharmacogenomics: untapped potential for translation
Idris Guessous1, Marta Gwinn, Muin J Khoury
1Emory University, Rollins School of Public Health Department of Epidemiology, Grace Crum Rollins Building, 1518 Clifton Road, Atlanta, Georgia 30322, USA. goq3@cdc.gov.
Abstract:
Despite large public investments in genome-wide association studies of common human diseases, so far, few gene discoveries have led to applications for clinical medicine or public health. Genome-wide association studies in the context of clinical trials of drug safety and efficacy may be quicker to yield clinical applications. Certain methodological concerns, such as selection bias and confounding, may be mitigated when genome-wide association studies are conducted within clinical trials, in which randomization of exposure, prospective evaluation of outcome and careful definition of phenotype are incorporated by design.
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Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
