Related Experiment Video
Updated: Jun 23, 2026

Application of Genetically Encoded Fluorescent Nitric Oxide (NO•) Probes, the geNOps, for Real-time Imaging of NO• Signals in Single Cells
Published on: March 16, 2017
A hypothesis about cellular signaling with nitric oxide in the earliest life forms in evolution
1Department of Integrative Biology and Pharmacology, Institute of Molecular Medicine and University of Texas Health Science Center, Houston, TX 77030, USA. Ferid.Murad@uth.tmc.edu
Abstract:
We propose that nitric oxide participated as an extracellular and intracellular messenger in the early evolution of life. From a toxic and noxious substance it evolved into an important material for cellular communication and regulation with unique chemistry and properties. The presence of some nitric oxide complexes in extraterrestrial samples may support evidence for life forms in the past or present. Although nitric oxide probably participated in the evolution and maintenance of life, if pollution continues at an ever-increasing rate, it could also end life on the planet as we know it today.
Related Concept Videos
Nitric Oxide Signaling Pathway
Origin of Cellular Life
Types of Signaling Molecules
Types of Signaling Molecules
Overview of Cell Signaling
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
Overview of Cell Signaling
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...

