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Updated: Jun 23, 2026

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Signaling pathways regulating zebrafish lateral line development.

Eva Y Ma1, David W Raible

  • 1University of Washington, Box 357420, Seattle, WA 98195-7420, USA.

Current Biology : CB
|May 15, 2009
PubMed
Summary
This summary is machine-generated.

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Zebrafish lateral line organ development relies on FGF, Wnt/beta-catenin, and Notch signaling. These pathways regulate its formation, patterning, migration, cell fate, and regeneration after hair cell loss.

Area of Science:

  • Developmental Biology
  • Sensory Organ Development
  • Regenerative Medicine

Background:

  • The lateral line organ is a crucial mechanosensory system in fish and amphibians, detecting water flow.
  • Zebrafish serve as a powerful model organism for studying cell polarity, collective cell migration, and hair cell regeneration.

Purpose of the Study:

  • To summarize recent findings on signaling pathways governing posterior lateral line development in zebrafish.
  • To elucidate the roles of FGF, Wnt/beta-catenin, and Notch pathways in lateral line organ formation and regeneration.

Main Methods:

  • Utilized genetic tools in zebrafish to investigate signaling pathways.
  • Employed live imaging techniques for real-time observation of developmental processes.

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Last Updated: Jun 23, 2026

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11:17

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Published on: May 20, 2020

Microbead Implantation in the Zebrafish Embryo
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Microbead Implantation in the Zebrafish Embryo

Published on: July 30, 2015

Activity of Posterior Lateral Line Afferent Neurons during Swimming in Zebrafish
10:34

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Published on: February 10, 2021

Main Results:

  • Identified critical roles for FGF, Wnt/beta-catenin, and Notch signaling in posterior lateral line primordium formation.
  • Demonstrated pathway involvement in organ patterning, collective cell migration, and cell fate specification.
  • Highlighted the significance of these pathways in hair cell regeneration following loss.

Conclusions:

  • FGF, Wnt/beta-catenin, and Notch signaling pathways are essential regulators of zebrafish lateral line organ development and regeneration.
  • Understanding these pathways provides insights into mechanosensory organ development and repair mechanisms.