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Related Experiment Videos

Intravenous contrast media: use and associated mortality.

J D Cashman1, J McCredie, D A Henry

  • 1Royal North Shore Hospital, St Leonards, NSW.

The Medical Journal of Australia
|November 4, 1991
PubMed
Summary

Death from intravenous contrast media injections is rare, with an overall mortality of 13 per million. This study found no evidence that newer low osmolar contrast media reduced mortality compared to older high osmolar media.

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Area of Science:

  • Radiology and Imaging
  • Public Health
  • Pharmacovigilance

Background:

  • Peripheral intravenous injections of radiocontrast media are common diagnostic procedures.
  • Assessing the safety and utilization of these agents is crucial for patient care.
  • Previous data on the incidence and mortality associated with radiocontrast media use is limited.

Purpose of the Study:

  • To determine the extent of use of peripheral intravenous radiocontrast media.
  • To ascertain the mortality rates associated with these injections.
  • To compare the safety profiles of low osmolar versus high osmolar contrast media.

Main Methods:

  • Retrospective analysis of injection data from January 1987 to June 1990.
  • Utilized Health Insurance Commission database and public hospital x-ray department records.

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  • Gathered mortality data through a survey of radiologists and other relevant sources.

    • Main Results:

    • Over 613,000 intravenous contrast injections were administered in New South Wales and the Australian Capital Territory.
    • The overall annual incidence of use was 2.9%, higher in individuals over 65 years (over 7%).
    • Eight deaths were documented, yielding an overall mortality of 13 per million injections, with higher rates in those over 65.

    Conclusions:

    • Mortality associated with intravenous contrast media injection is a rare occurrence.
    • No significant difference in mortality was observed between low osmolar and high osmolar contrast media.
    • Further research may be warranted to explore specific risk factors and refine safety protocols.