Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Esophageal Perforation-I: Introduction

Esophageal Perforation-I: Introduction

Esophageal perforation is a severe medical condition characterized by a breach in the integrity of the esophageal wall. This breach can occur due to various factors such as trauma, medical procedures, or underlying diseases. When the esophageal wall is compromised, it allows food, fluids, and digestive juices into the chest cavity or adjacent structures, leading to potential complications and health risks.
The location of esophageal perforation can vary, occurring anywhere along the esophagus.

Protein Import into the Peroxisomes

Protein Import into the Peroxisomes

Cells contain membrane-bound organelles called peroxisomes that oxidize organic molecules by transferring hydrogen atoms to oxygen, producing hydrogen peroxide. Peroxisomes enzymatically convert the released hydrogen peroxide into water and oxygen.
Peroxisomal Protein Import:
Peroxisomes lack the genetic machinery required to code for their own proteins. Hence, most peroxisomal membrane, lumenal and transmembrane proteins are synthesized in the cytoplasm or ER and transported to the peroxisome...

Esophageal Perforation-II: Clinical Manifestations and Management

Esophageal Perforation-II: Clinical Manifestations and Management

Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:

Chronic Obstructive Pulmonary Disease II: Emphysema

Chronic Obstructive Pulmonary Disease II: Emphysema

Emphysema, a major phenotype of chronic obstructive pulmonary disease (COPD), is characterized by irreversible destruction of alveolar walls and permanent enlargement of distal airspaces. Unlike chronic bronchitis, which primarily affects the airways, emphysema predominantly involves the lung parenchyma, where structural damage leads to airflow limitation.PathophysiologyIt most commonly results from prolonged exposure to cigarette smoke and other toxic gases, particularly cigarette smoke.

Peptic Ulcer

Peptic Ulcer

Peptic ulcers are erosive lesions of the gastric or duodenal lining, most commonly caused by Helicobacter pylori infection. This Gram-negative, helical bacterium has adapted to survive the stomach’s acidic environment by producing urease, which converts urea into ammonia and carbon dioxide. The ammonia neutralizes gastric acid in the bacterium’s immediate environment, allowing colonization of the gastric mucosa. H. pylori attaches to mucus-secreting epithelial cells, penetrates the mucus...

Peritoneum

Peritoneum

The peritoneum is a vital membrane that lines the abdominal cavity and covers most of the organs within it. It plays a crucial role in protecting the organs, providing a smooth surface for their movement, and facilitating various physiological processes. Understanding the anatomy and function of the peritoneum is essential for comprehending the complexities of the abdominal region.
Anatomy of the Peritoneum
The peritoneum is divided into two layers: the parietal peritoneum and the visceral...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Insights into Pathogenesis of Chronic Spontaneous Urticaria.

The British journal of dermatology·2026

Same author

Biomarkers in atopic dermatitis: Current evidence and unmet needs.

Journal of the European Academy of Dermatology and Venereology : JEADV·2026

Same author

Treatment Approaches for Omalizumab-Refractory Chronic Spontaneous Urticaria.

Journal of inflammation research·2026

Same author

Global Real-World Validation of First-Day Urticaria Activity Score (UAS1).

The journal of allergy and clinical immunology. In practice·2026

Same author

Clinical phenotypes and molecular endotypes of chronic urticaria: Linking clinical expression to underlying immune mechanisms.

Asia Pacific allergy·2026

Same author

The Overall Burden of Chronic Spontaneous Urticaria - The Current Landscape.

The British journal of dermatology·2026

Search research articles

Related Experiment Video

Updated: Jun 23, 2026

A Mouse Abdominal Aortic Aneurysm Model by Periadventitial Calcium Chloride and Elastase Infiltration

A Mouse Abdominal Aortic Aneurysm Model by Periadventitial Calcium Chloride and Elastase Infiltration

Published on: August 2, 2024

Periumbilical perforating pseudoxanthoma elasticum.

Emek Kocatürk¹, Mukaddes Kavala, Ilkin Zindanci

¹Goztepe Training and Research Hospital, Department of Dermatology, Istanbul, Turkey. emekozgur@yahoo.com

Indian Journal of Dermatology, Venereology and Leprology

|May 15, 2009

Summary

A rare skin condition, perforating pseudoxanthoma elasticum, can develop perforations due to mechanical triggers. This case highlights how external factors may influence the progression of this hereditary disorder.

More Related Videos

Elastic Staining on Paraffin-embedded Slides of pT3N0M0 Gastric Cancer Tissue

Elastic Staining on Paraffin-embedded Slides of pT3N0M0 Gastric Cancer Tissue

Published on: May 1, 2019

Related Experiment Videos

Last Updated: Jun 23, 2026

A Mouse Abdominal Aortic Aneurysm Model by Periadventitial Calcium Chloride and Elastase Infiltration

A Mouse Abdominal Aortic Aneurysm Model by Periadventitial Calcium Chloride and Elastase Infiltration

Published on: August 2, 2024

Elastic Staining on Paraffin-embedded Slides of pT3N0M0 Gastric Cancer Tissue

Elastic Staining on Paraffin-embedded Slides of pT3N0M0 Gastric Cancer Tissue

Published on: May 1, 2019

Area of Science:

Dermatology
Genetics
Pathology

Background:

Pseudoxanthoma elasticum (PXE) is a rare genetic disorder affecting elastic tissues.
Perforating pseudoxanthoma elasticum (PPXE) is a variant characterized by transepidermal elimination of abnormal elastic fibers.

Observation:

A 58-year-old obese woman presented with a 3-year history of pruritic, yellowish plaques around the umbilicus and flat yellow papules on the axilla and neck.
A burn injury to the abdominal plaque resulted in the development of perforating papules and a violaceous hue.

Findings:

Histological examination revealed pathological elastic fibers with keratotic plugs and dermal perforation.
The findings were consistent with perforating pseudoxanthoma elasticum.

Implications:

This case suggests that mechanical factors, such as thermal injury, can induce or exacerbate perforation in PPXE.
Understanding these triggers is crucial for managing patients with this rare hereditary condition and preventing complications.