Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Colicin V virulence plasmids.

V L Waters1, J H Crosa

  • 1Department of Microbiology and Immunology, Oregon Health Sciences University, Portland 97201.

Microbiological Reviews
|September 1, 1991
PubMed
Summary

ColV plasmids enhance Escherichia coli virulence through iron uptake and serum resistance. Further research is needed to characterize other ColV-encoded traits and their role in pathogenesis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Putative virulence-related genes in Vibrio anguillarum identified by random genome sequencing.

Journal of fish diseases·2006
Same author

Conjugation between bacterial and mammalian cells.

Nature genetics·2001
Same author

Genetic organization of the region encoding regulation, biosynthesis, and transport of rhizobactin 1021, a siderophore produced by Sinorhizobium meliloti.

Journal of bacteriology·2001
Same author

The overlapping angB and angG genes are encoded within the trans-acting factor region of the virulence plasmid in Vibrio anguillarum: essential role in siderophore biosynthesis.

Journal of bacteriology·2000
Same author

Characterization of the DNA- and metal-binding properties of Vibrio anguillarum fur reveals conservation of a structural Zn(2+) ion.

Journal of bacteriology·2000
Same author

Characterization of the angR gene of Vibrio anguillarum: essential role in virulence.

Infection and immunity·1999

Area of Science:

  • Microbiology
  • Genetics
  • Bacterial Pathogenesis

Background:

  • ColV plasmids are IncFI plasmids associated with virulence in invasive Escherichia coli.
  • These plasmids confer traits like aerobactin iron uptake, serum survival, and phagocytosis resistance.
  • ColV plasmids infect vertebrate hosts, including humans and livestock.

Purpose of the Study:

  • To systematically study ColV plasmids and their encoded virulence factors.
  • To investigate uncharacterized ColV-encoded phenotypes beyond the aerobactin system.
  • To understand the role of large plasmids in bacterial pathogenesis and host-pathogen interactions.

Main Methods:

  • Restriction enzyme mapping of ColV plasmids (e.g., pColV-K30, pColV-B188).
  • Molecular and comparative approaches to analyze virulence factors.
  • Utilizing model systems to study E. coli virulence.

Main Results:

  • Characterization of the aerobactin iron uptake system encoded by pColV-K30.
  • Identification of other virulence-related properties conferred by ColV plasmids.
  • Restriction mapping facilitated systematic study of plasmid structure and function.

Conclusions:

  • ColV plasmids are significant contributors to E. coli virulence.
  • Further research on ColV plasmids can illuminate bacterial pathogenesis.
  • Insights into ColV plasmids may inform our understanding of other large virulence plasmids.

Related Experiment Videos