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Colicin V virulence plasmids.

V L Waters1, J H Crosa

  • 1Department of Microbiology and Immunology, Oregon Health Sciences University, Portland 97201.

Microbiological Reviews
|September 1, 1991
PubMed
Summary
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ColV plasmids enhance Escherichia coli virulence through iron uptake and serum resistance. Further research is needed to characterize other ColV-encoded traits and their role in pathogenesis.

Area of Science:

  • Microbiology
  • Genetics
  • Bacterial Pathogenesis

Background:

  • ColV plasmids are IncFI plasmids associated with virulence in invasive Escherichia coli.
  • These plasmids confer traits like aerobactin iron uptake, serum survival, and phagocytosis resistance.
  • ColV plasmids infect vertebrate hosts, including humans and livestock.

Purpose of the Study:

  • To systematically study ColV plasmids and their encoded virulence factors.
  • To investigate uncharacterized ColV-encoded phenotypes beyond the aerobactin system.
  • To understand the role of large plasmids in bacterial pathogenesis and host-pathogen interactions.

Main Methods:

  • Restriction enzyme mapping of ColV plasmids (e.g., pColV-K30, pColV-B188).
  • Molecular and comparative approaches to analyze virulence factors.

Related Experiment Videos

  • Utilizing model systems to study E. coli virulence.

    • Main Results:

    • Characterization of the aerobactin iron uptake system encoded by pColV-K30.
    • Identification of other virulence-related properties conferred by ColV plasmids.
    • Restriction mapping facilitated systematic study of plasmid structure and function.

    Conclusions:

    • ColV plasmids are significant contributors to E. coli virulence.
    • Further research on ColV plasmids can illuminate bacterial pathogenesis.
    • Insights into ColV plasmids may inform our understanding of other large virulence plasmids.