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Updated: Jun 23, 2026

A Simplified System for Evaluating Cell Mechanosensing and Durotaxis In Vitro
Published on: August 27, 2015
Molecular mechanisms of mechanosensing in muscle development
Klodiana Jani1, Frieder Schöck
1Department of Biology, McGill University, Montréal, Québec, Canada. klodiana.jani@elf.mcgill.ca
Abstract:
Mechanical forces are crucial to muscle development and function, but the mechanisms by which forces are sensed and transduced remain elusive. Evidence implicates the sarcolemmal lattice of integrin adhesion and the Z-disk components of the contractile machinery in such processes. These mechanosensory devices report changes in force to other cellular compartments by self-remodeling. Here we explore how their structural and functional properties integrate to regulate muscle development and maintenance. Developmental Dynamics 238:1526-1534, 2009. (c) 2009 Wiley-Liss, Inc.
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