[Stellanin-PEG 3% ointment: comparative antimicrobial activity against surgical infection pathogens]

Area of Science:

• Pharmacology and Microbiology
• Antimicrobial Agents and Drug Discovery

Background:

• Pyoinflammatory processes in surgical patients are often caused by challenging microbial pathogens.
• The need for effective topical antimicrobial agents is critical in managing surgical site infections.

Purpose of the Study:

• To comparatively evaluate the antimicrobial activity of four topical ointments: Stellanin-PEG, Levomecole, Dioxydin 5% ointment, and Betadine.
• To assess the efficacy of these ointments against common pathogens responsible for surgical infections.

Main Methods:

• Utilized a panel of standard microbial strains and clinical isolates representing frequent pathogens in surgical patients.
• Tested both Gram-positive and Gram-negative bacteria, including antibiotic-resistant strains like methicillin-resistant Staphylococcus aureus (MRSA).
• Evaluated the activity of Stellanin-PEG at 3% and 5% concentrations against E. faecalis, E. faecium, E. coli, and Klebsiella spp. producing extended-spectrum beta-lactamases (ESBLs).

Main Results:

• Stellanin-PEG 3% ointment exhibited potent antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative organisms.
• This activity extended to challenging pathogens, including MRSA, E. faecalis, E. faecium, E. coli, and ESBL-producing Klebsiella spp.
• Stellanin-PEG 5% ointment demonstrated efficacy comparable to, though slightly inferior to, 5% Dioxydin ointment.

Conclusions:

• Stellanin-PEG possesses significant broad-spectrum antimicrobial properties, effective against key pathogens in surgical infections.
• Its efficacy against resistant strains highlights its potential as a valuable therapeutic agent in topical antimicrobial treatment.
• Stellanin-PEG represents a promising alternative or adjunct in managing pyoinflammatory conditions in surgical settings.