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[Bone marrow transplantation for pediatric solid tumor].

S Yokoyama1, H Hirakawa, T Tajima

  • 1Department of Surgery, Tokai University, School of Medicine, Isehara, Japan.

Nihon Geka Gakkai Zasshi
|September 1, 1991
PubMed
Summary
This summary is machine-generated.

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Bone marrow transplantation·2017

Bone marrow transplantation (BMT) allows intensive cancer therapy in children with advanced solid tumors. This approach resulted in a 53% survival rate, establishing it as a viable treatment option despite severe toxicity.

Area of Science:

  • Oncology
  • Hematology
  • Pediatric Medicine

Context:

  • Bone marrow transplantation (BMT) enables high-dose chemotherapy and radiotherapy for cancer treatment.
  • Pediatric solid tumors often present in advanced stages, posing significant treatment challenges.

Purpose:

  • To evaluate the efficacy and outcomes of BMT in children with disseminated solid tumors.
  • To assess the feasibility of intensified cytoreductive therapy using BMT for advanced pediatric cancers.

Summary:

  • Fifteen children with advanced solid tumors (including neuroblastoma, lymphoma, PNET, hepatoblastoma, and yolk sac tumors) received BMT.
  • Eight out of 15 patients (53%) remained alive and well at a median of 45 months post-transplant.
  • The study highlights that high-dose chemo-radiotherapy with BMT, following remission induction, is a crucial treatment for advanced pediatric solid tumors.

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Impact:

  • BMT offers a potentially life-saving option for children with previously intractable disseminated solid tumors.
  • Despite severe toxicity, BMT demonstrates significant long-term survival benefits in this pediatric oncology population.
  • This research supports the integration of BMT into treatment protocols for advanced-stage pediatric malignant solid tumors.