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Related Experiment Video

Updated: Jun 23, 2026

Mast Cells in the Microenvironment of Hepatocellular Carcinoma Confer Favorable Prognosis: A Retrospective Study using QuPath Image Analysis Software

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Published on: April 12, 2024

[Mastocytosis: when should it be considered?].

Sophie Comte-Perret¹, Pierre-Alexandre Bart, François Spertini

¹Service d'immunologie et d'allergie, CHUV, 1011 Lausanne. sophie.comte@chuv.ch

Revue Medicale Suisse

|May 16, 2009

Summary

This summary is machine-generated.

Mast cell disorders involve abnormal mast cell accumulation, causing symptoms through mediator release or organ infiltration. Diagnosis and treatment have advanced, with new options targeting mast cell proliferation.

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Area of Science:

Hematology
Immunology
Dermatology

Background:

Mast cell disorders are characterized by the accumulation of mast cells in various organ systems.
Cutaneous forms are more common in children, while systemic forms predominantly affect adults.

Observation:

Mast cells trigger symptoms via the release of proinflammatory mediators or by infiltrating organs.
Elevated serum tryptase levels can indicate mastocytosis, especially following severe anaphylactic reactions.

Findings:

Definitive diagnosis relies on skin or bone marrow biopsies.
Activating mutations in the stem cell factor receptor c-kit are frequently identified.
Current treatments focus on managing symptoms from mast cell degranulation.

Implications:

Serum tryptase measurement aids in screening for mastocytosis.
Novel therapies targeting mast cell proliferation are becoming clinically available.
Understanding mast cell disorders is crucial for managing allergic and inflammatory conditions.