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Related Concept Videos

Mass Analyzers: Common Types01:19

Mass Analyzers: Common Types

The quadrupole mass analyzer consists of four cylindrical metal rods arranged in a diamond carrying a DC voltage and a radio-frequency AC voltage. The motion of ions through the quadrupole depends on the field strength, causing only ions of a certain m/z to resonate successfully and strike the detector at a given field strength. Though the transmission rate for these analyzers is high, the exact elemental composition of the sample is not determined because of low resolution; however, they are...
Mass Analyzers: Overview01:13

Mass Analyzers: Overview

The mass analyzer is a crucial component of the mass spectrometer. In the ionization chamber, the vaporized sample is bombarded with a high-energy electron beam to generate a radical cation and further fragment into neutral molecules, radicals, and cations. A series of negatively charged accelerator plates accelerate the cations into the mass analyzer. The mass analyzer separates ions according to their mass-to-charge (m/z) ratios and then directs them to the detector. The common types of mass...
MALDI-TOF Mass Spectrometry01:19

MALDI-TOF Mass Spectrometry

Mass spectrometry is a powerful characterization technique that can identify and separate a wide variety of compounds ranging from chemical to biological entities, based on their mass-to-charge ratio (m/z). The instruments that allow this detection, known as mass spectrometers, have three components: an ion source, a mass analyzer, and a detector. These spectrometers differ based on the nature of their ion source and analyzers.Matrix-assisted laser desorption ionization (MALDI) is a commonly...
Mass Spectrometers01:16

Mass Spectrometers

This lesson details the instrumentation of a mass spectrometer—a physical instrument to perform mass spectrometry on analyte molecules and record the characteristic mass spectra. This is achieved via three chief functions:
Tandem Mass Spectrometry01:21

Tandem Mass Spectrometry

Tandem mass spectrometry is a technique that uses multiple mass analyzers in series to obtain a higher selectivity and reduce chemical noise during analyte detection. Instruments with multiple analyzers separated by an interaction cell enable secondary fragmentation and selected study of the fragment ions.Secondary fragmentations occur in the interaction cell and can be induced by various factors. Fragmentation induced by collision with inert gases, such as N2, Ar, He, etc., is called...
Mass Spectrometry: Complex Analysis01:21

Mass Spectrometry: Complex Analysis

Mass spectrometry is an important technique for the identification of pure compounds. However, it has some limitations for the analysis of complex mixtures, often due to excessive fragmentation making the spectrum too complicated to decipher. Mass spectrometry can be combined with suitable separation methods in sequence, forming hyphenated methods, which are useful in the analysis of complex mixtures.
GC–MS is a powerful hyphenated method commonly used in forensics and environmental...

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Analyzing Protein Architectures and Protein-Ligand Complexes by Integrative Structural Mass Spectrometry
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Published on: October 15, 2018

Ion trap array mass analyzer: structure and performance.

Xiaoxu Li1, Gongyu Jiang, Chan Luo

  • 1Laser Chemistry Institute and Department of Chemistry, Department of Electronic Engineering, Fudan University, 220 Handan Road, Shanghai 200433, China.

Analytical Chemistry
|May 16, 2009
PubMed
Summary

A novel ion trap array (ITA) mass analyzer was developed, enabling simultaneous ion trapping, storage, and analysis across multiple channels. This compact and cost-effective device promises miniaturized mass spectrometry and high-throughput analysis.

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Area of Science:

  • Analytical Chemistry
  • Mass Spectrometry Instrumentation
  • Physical Chemistry

Background:

  • Traditional mass analyzers face limitations in throughput and miniaturization.
  • Developing novel architectures for ion manipulation is crucial for advancing analytical capabilities.

Purpose of the Study:

  • To design, construct, and evaluate a novel ion trap array (ITA) mass analyzer.
  • To explore the potential of the ITA for simultaneous multi-channel ion analysis.
  • To assess the ITA's performance, including mass resolution and specialized ion manipulation functions.

Main Methods:

  • Fabrication of an ITA using printed circuit board (PCB) technology with multiple parallel electrode strips.
  • Application of radiofrequency (rf) voltages to adjacent strips with opposite polarity to create multiple electric field regions.
  • Experimental operation in both 'digital ion trap mode' and 'conventional rf mode'.
  • Testing of mass spectrum acquisition, mass-selected ion isolation, and ion ejection functionalities.

Main Results:

  • The ITA successfully demonstrated ion trapping, storage, and mass analysis functions across multiple channels.
  • A preliminary mass spectrum achieved a mass resolution exceeding 1000.
  • Functions like mass-selected ion isolation and ejection were experimentally validated.
  • The ITA exhibits a compact size (e.g., <30 cm³ for a four-channel unit) and low cost.

Conclusions:

  • The developed ion trap array represents a significant advancement in mass spectrometry instrumentation.
  • The ITA's multi-channel capability and compact design offer a promising platform for miniaturized and high-throughput mass analysis.
  • This technology holds potential for widespread application in various analytical fields requiring efficient and scalable mass spectrometry.