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Updated: Jun 23, 2026
07:41
A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
Published on: February 20, 2018
Chemokine receptor antagonists: Part 1
1Faculty of Medicine National Heart and Lung Institute, Imperial College of Science, Technology & Medicine, Leukocyte Biology Section, South Kensington Campus, London SW7 2AZ, UK. j.pease@imperial.ac.uk
Expert Opinion on Therapeutic Patents
|May 16, 2009
Summary
Chemokine receptor antagonists targeting CCR1-4 show promise for autoimmune diseases and AIDS. While clinical success is pending, these compounds offer valuable insights for future therapeutic development.
Area of Science:
- Immunology
- Pharmacology
Background:
- Chemokines are immune cell chemoattractants with roles beyond host defense, including growth regulation and angiogenesis.
- Chemokines and their receptors are implicated in autoimmune diseases and AIDS, making them pharmaceutical targets.
- Chemokine receptors are part of the G-protein-coupled receptor superfamily.
Purpose of the Study:
- To review recent developments in chemokine receptor antagonist research.
- Focus on antagonists for CC chemokine receptors CCR1, CCR2, CCR3, and CCR4.
- Analysis of both peer-reviewed and patent literature.
Main Methods:
- Literature review of peer-reviewed publications.
- Analysis of patent literature.
- Focus on CC chemokine receptors (CCR1-4).
Main Results:
- Several chemokine receptor antagonists have advanced from lead compounds to clinical candidates.
- The review covers recent progress in the antagonist field for CCR1, CCR2, CCR3, and CCR4.
Conclusions:
- No clinical success has been achieved yet for antagonists targeting these specific receptors.
- The developed compounds provide valuable data for future therapeutic strategies.
- Further research may lead to successful therapeutics for chemokine-mediated diseases.
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