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Chemokine receptor antagonists: part 2.

James E Pease1, Richard Horuk

  • 1Faculty of Medicine National Heart and Lung Institute, Imperial College of Science, Technology & Medicine, Leukocyte Biology Section, London, UK. j.pease@imperial.ac.uk

Expert Opinion on Therapeutic Patents
|May 16, 2009
PubMed
Summary

This review covers chemokine receptor antagonists, focusing on CCR5, CCR8, CCR9, CXCR3, and CXCR4. While maraviroc (CCR5 inhibitor) is approved for AIDS, many antagonists have failed, prompting interest in promiscuous receptor antagonists.

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