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Related Experiment Videos

[The artificial heart: present status and future prospects].

H Takano1, Y Taenaka, T Nakatani

  • 1Department of Artificial Organs, National Cardiovascular Center Research Institute, Suita, Japan.

Nihon Geka Gakkai Zasshi
|September 1, 1991
PubMed
Summary

Temporary artificial hearts (AH) offer cardiac support for severe heart failure, with ventricular assist systems (VASs) and total artificial hearts (TAHs) showing limited survival. Future research focuses on long-term implantable AH as an alternative to heart transplantation (HTx).

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Journal of Artificial Organs 2019: the year in review : Journal of Artificial Organs Editorial Committee.

Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs·2020

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Surgery
  • Regenerative Medicine

Context:

  • Artificial heart (AH) and heart transplantation (HTx) are crucial for cardiac replacement.
  • Temporary AH, including ventricular assist systems (VASs) and total artificial hearts (TAHs), are used for acute heart failure.
  • Current donor heart supply is insufficient for the number of candidates, necessitating alternatives like AH.

Purpose:

  • To review the current status and future prospects of artificial hearts (AH) as alternatives to heart transplantation (HTx).
  • To highlight the key components required for developing high-performance, long-term implantable AH.
  • To discuss emerging AH technologies and their potential impact on cardiac replacement therapy.

Summary:

  • Temporary ventricular assist systems (VASs) and total artificial hearts (TAHs) have been clinically applied to patients with profound heart failure, with reported short-term survival rates.

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  • A significant number of patients utilize VAS and TAH as a bridge to heart transplantation (HTx) due to donor organ scarcity.
  • Development of long-term implantable AH requires advancements in biomaterials, actuators, monitoring systems, control systems, and energy converters.
  • Emerging technologies include muscle-powered biomechanical AH, artificial muscle-powered AH, and integrated artificial heart-lung devices.

    • Impact:

    • The development of totally implantable permanent AH could provide a viable alternative to heart transplantation for patients with end-stage heart failure.
    • Advancements in AH technology promise to improve patient outcomes and quality of life.
    • This research paves the way for future innovations in artificial organ development and cardiac support.