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Related Experiment Video

Updated: Jun 23, 2026

A Fluorescence-based Protocol for Preliminary Screening of Protein Synthesis Inhibitors from Natural Sources

A Fluorescence-based Protocol for Preliminary Screening of Protein Synthesis Inhibitors from Natural Sources

Published on: January 27, 2026

ING proteins as potential anticancer drug targets.

M Unoki¹, K Kumamoto, C C Harris

¹Laboratory for Biomarker, The Institute of Physical and Chemical Research, RIKEN, Tokyo 108-8639, Japan.

Current Drug Targets

|May 16, 2009

Summary

ING2, initially thought to be a tumor suppressor, acts as an oncogene in some cancers. Targeting ING2 may offer a novel anticancer therapy by inhibiting cancer cell invasion and promoting apoptosis.

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Area of Science:

Molecular Biology
Oncology
Cancer Research

Background:

ING family proteins have dual roles in carcinogenesis, acting as oncogenes or tumor suppressors.
Previous studies suggested ING proteins were tumor suppressors due to their ability to induce apoptosis or cell cycle arrest.

Purpose of the Study:

To review the dual role of ING2 in cancer, focusing on its oncogenic functions and potential as a therapeutic target.
To discuss the clinical implications of targeting ING2 in molecular targeted therapies.

Main Methods:

Review of recent evidence on ING2 function, including knockdown experiments and isoform analysis.
Analysis of ING2 expression in colorectal cancer and its role in invasion via MMP13.

Main Results:

ING2 knockdown induces senescence in normal cells and suppresses cancer cell growth.
ING2 is overexpressed in colorectal cancer, promoting invasion through MMP13.
Both ING2a and ING2b isoforms confer resistance to apoptosis and cell cycle arrest in cancer cells.

Conclusions:

ING2 functions as an oncogene in specific cancer types, contradicting earlier suppressor gene hypotheses.
Knockdown of ING2 inhibits cancer cell invasion and induces apoptosis, identifying it as a potential anticancer drug target.
Targeting ING2 offers a promising strategy for molecular targeted cancer therapies.