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Proteomic identification of a monoclonal antibody recognizing caveolin-1 in hepatocellular carcinoma with metastatic
Mei-yu Hu1, Chi-tat Lam, Kang-da Liu
1Experiment Research Center, Zhongshan Hospital, Fudan University, Shanghai, China. liu.kangda@zs-hospital.sh.cn
Protein and Peptide Letters
|May 16, 2009
Abstract:
A monoclonal antibody, McAb9E (IgG3), was generated against a metastatic HCC cell line, MHCC-1. The antigen was characterized as human Caveolin-1 (Cav-1, 21kDa), with pI of 5.65. The Cav-1 antigen was found significantly over expressed in metastatic HCC cell lines as well as in tumor specimens. The Cav-1 specific McAb may be a useful molecular agent for metastatic HCC.
