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Updated: Jun 23, 2026
07:56
Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
Published on: January 29, 2018
DMPA's effect on bone mineral density: A particular concern for adolescents
1Department of Family Medicine, University of Wisconsin, 777 South Mills Street, Madison, WI 53715, USA. sbschrag@wisc.edu
The Journal of Family Practice
|May 16, 2009
Summary
Depot-medroxyprogesterone acetate (DMPA) may decrease bone mineral density. Women using DMPA for contraception should supplement with calcium and vitamin D, and consider estrogen replacement for long-term use.
Area of Science:
- Endocrinology
- Bone Metabolism
- Reproductive Health
Background:
- Depot-medroxyprogesterone acetate (DMPA) is a widely used injectable contraceptive.
- Concerns exist regarding its potential impact on bone mineral density (BMD).
Purpose of the Study:
- To discuss the potential for decreased bone mineral density in women using DMPA for contraception.
- To provide recommendations for mitigating bone loss associated with DMPA use.
Main Methods:
- Literature review on DMPA and bone health.
- Analysis of existing data on BMD changes in DMPA users.
- Formulation of clinical recommendations based on current evidence.
Main Results:
- DMPA use is associated with a potential decrease in bone mineral density.
- Supplementation with calcium and vitamin D may help counteract bone loss.
- Estrogen replacement therapy is a consideration for extended DMPA use.
Conclusions:
- Women considering DMPA contraception should be informed about potential BMD effects.
- Adequate calcium and vitamin D intake is recommended during DMPA use.
- Long-term DMPA users may benefit from estrogen replacement therapy to preserve bone health.
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