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Angioimmunoblastic T-cell lymphoma with autoimmune thrombocytopenia: a report of two cases
Kuniyuki Oka1, Reizo Nagayama, Yasushi Yatabe
1Pathology, Mito Saiseikai General Hospital, Mito, Ibaraki 311-4198, Japan. oka-k@gb3.so-net.ne.jp
Abstract:
We report two patients, a 68-year-old man (Case 1) and a 66-year-old man (Case 2), with polyclonal gammopathy, lymphadenopathy, thrombocytopenia, and high platelet-associated IgG (PAIgG) level. We initially diagnosed them as having angioimmunoblastic lymphadenopathy with dysproteinemia (AILD). From confirmation of clear cells by careful observation and detection of rearrangement bands of T cell receptors by Southern blot hybridization analysis, we finally concluded that their diagnoses were compatible with angioimmunoblastic T-cell lymphoma (AILT). AILT with autoimmune thrombocytopenia (AIT) is very rare, and all the reported cases were Japanese ones.