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Time-Resolved, Dynamic Computed Tomography Angiography for Characterization of Aortic Endoleaks and Treatment Guidance via 2D-3D Fusion-Imaging
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Effect of cardiac function on aortic peak time and peak enhancement during coronary CT angiography

Shuji Sakai1, Hidetake Yabuuchi, Akiko Chishaki

  • 1Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. sakai@shs.kyushu-u.ac.jp

European Journal of Radiology
|May 16, 2009
PubMed

Insights

Cardiac function significantly impacts aortic contrast enhancement timing and magnitude during coronary CT angiography (CTA). Higher cardiac index correlates with decreased aortic peak time and enhancement.

Area of Science:

  • Cardiovascular Imaging
  • Radiology
  • Cardiac Physiology

Background:

  • Coronary CT angiography (CTA) is crucial for diagnosing coronary artery disease.
  • Optimizing contrast enhancement in CTA is essential for accurate image interpretation.
  • Cardiac function is a potential modulator of contrast dynamics in CTA.

Purpose of the Study:

  • To investigate the relationship between cardiac function and aortic contrast enhancement during coronary CTA.
  • To determine how cardiac output and cardiac index influence the timing and magnitude of aortic enhancement.

Main Methods:

  • Twenty-nine patients underwent cardiac output measurement (thermodilution) near coronary CTA.
  • Aortic attenuation was measured every 3 seconds during CTA to determine aortic peak time (APT) and aortic peak enhancement (APE).
  • Statistical analysis (Pearson's correlation) assessed relationships between cardiac function parameters and APT/APE.

Main Results:

  • A higher cardiac index was significantly associated with a decreased APT (r=-0.698, p<0.0001) and APE (r=-0.573, p=0.0009).
  • Patient body weight also showed significant correlations with APT and APE.
  • Test bolus injection parameters correlated with APT and APE during the main CTA acquisition.

Conclusions:

  • Cardiac function, specifically cardiac index, is a key determinant of aortic contrast enhancement patterns in coronary CTA.
  • Understanding these relationships can help optimize CTA protocols and image interpretation.
Abstract

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