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Intestinal mucosal immune response in ducklings following oral immunisation with an attenuated Duck enteritis virus
Xiaoyan Yang1, Xuefeng Qi, Anchun Cheng
1Avian Disease Research Centre, College of Veterinary Medicine of Sichuan Agricultural University, Ya'an, Sichuan 625014, China.
Abstract:
To investigate the intestinal mucosal immune responses in ducklings orally inoculated with attenuated Duck enteritis virus (DEV), the kinetics of the viral load, the specific humoral immune responses, and the distribution of immunoglobulin (Ig)A-secreting cells in the intestine were evaluated. Oral inoculation with attenuated DEV stimulated an IgA-dominant response in intestinal secretions and a IgY-dominant response in the serum. The dramatic increase in virus-specific mucosal IgA 15 days after inoculation was accompanied by reductions in the DEV intestinal load, suggesting that the IgA response has a role in controlling viral replication. The kinetics of virus-specific IgA production closely correlated with the presence of IgA+ plasma cells in the intestinal lamina propria.
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