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Characterization of complementary DNA encoding the precursor for gonadotropin-releasing hormone and its associated
C T Bond1, R C Francis, R D Fernald
1Vollum Institute, Oregon Health Sciences University, Portland 97201.
Abstract:
Reproductive maturity among male African cichlids Haplochromis burtoni is cued by a series of environmental and social interactions and is mediated physiologically by GnRH. A cDNA clone encoding the precursor for GnRH was isolated from this teleost. The molecular architecture of the predicted prohormone is analogous to that of the previously characterized mammalian forms; however, the predicted sequence of the associated peptide is strikingly different. Attempts to isolate a putative second precursor using low stringency hybridization were not successful despite evidence that a second related decapeptide exists in at least some teleost species.
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