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Related Concept Videos

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
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Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

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Chronic Obstructive Pulmonary Disease II: Emphysema01:23

Chronic Obstructive Pulmonary Disease II: Emphysema

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Related Experiment Video

Updated: Jun 23, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

PLAUR polymorphisms are associated with asthma, PLAUR levels, and lung function decline.

Sheila J Barton1, Gerard H Koppelman, Judith M Vonk

  • 1Division of Infection, Inflammation and Immunity, School of Medicine, University of Southampton, Southampton, United Kingdom.

The Journal of Allergy and Clinical Immunology
|May 16, 2009
PubMed
Summary
This summary is machine-generated.

This study identifies the urokinase plasminogen activator receptor (PLAUR) gene as a potential asthma susceptibility gene. PLAUR variations influence asthma, lung function, and airway remodeling in asthma patients.

Related Experiment Videos

Last Updated: Jun 23, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Area of Science:

  • Genetics
  • Pulmonology
  • Biochemistry

Background:

  • Chromosome 19q13.1-3 is implicated in asthma susceptibility.
  • Previous studies suggest the presence of asthma-related genes in this chromosomal region.

Purpose of the Study:

  • To investigate the 19q13.1-3 region for asthma susceptibility genes.
  • To analyze linkage and association of genetic markers with asthma and related phenotypes.

Main Methods:

  • Utilized linkage and association analyses in 587 UK/Dutch asthma families (2819 subjects).
  • Employed a 3-phase approach: microsatellite analysis, SNP fine mapping, and dense gene analysis.
  • Evaluated associations with asthma, bronchial hyperresponsiveness (BHR), FEV1, plasma PLAUR levels, and FEV1 decline.

Main Results:

  • Microsatellite analysis suggested a locus for asthma/lung function susceptibility.
  • Fine mapping identified the urokinase plasminogen activator receptor (PLAUR) gene.
  • Specific PLAUR SNPs (5' region, intron 3, 3' region) associated with asthma, BHR, FEV1, plasma PLAUR levels, and FEV1 decline.

Conclusions:

  • PLAUR is identified as a novel potential asthma susceptibility gene.
  • Specific PLAUR regions influence asthma susceptibility, plasma PLAUR levels, and lung function decline.
  • Findings suggest PLAUR plays a role in airway remodeling in asthma.