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Updated: Jun 23, 2026
10:32
Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination
Published on: August 24, 2015
[Platelet transfusion: products, indications, dose, threshold and efficacy]
G Andreu1, J Vasse, R Tardivel
1Institut National de la Transfusion Sanguine, 75739 Paris cedex 15, France. gandreu@ints.fr
Summary
Platelet concentrate quality and safety have significantly improved, making apheresis and pooled random donor platelets largely equivalent. Key factors for effective platelet transfusion strategies include triggers, dose, and ABO compatibility.
Area of Science:
- Hematology
- Transfusion Medicine
Context:
- Platelet concentrate processing has evolved since the 1980s, with recent advances in safety through additive solutions and pathogen reduction.
- Current practices consider apheresis and pooled random donor platelet concentrates equivalent, except for allo-immunized patients.
Purpose:
- To review the physiological basis and efficacy evaluation of prophylactic and curative platelet transfusions.
- To discuss investigations for inefficient prophylactic transfusions and current guidelines.
- To explore recent data questioning established practices, such as in massive transfusion protocols.
Summary:
- Platelet transfusion is crucial for thrombocytopenia and other conditions, with established national guidelines.
- Recent developments enhance platelet component quality and safety.
- Critical factors for transfusion strategy include transfusion triggers, platelet dose, and ABO compatibility.
Impact:
- Improved platelet component quality and safety enhance transfusion efficacy.
- Equivalency of different platelet concentrate types simplifies transfusion protocols.
- Understanding critical factors optimizes platelet transfusion strategies and patient outcomes.
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