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Related Concept Videos

The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Renal Corpuscle01:20

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...

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Related Experiment Video

Updated: Jun 23, 2026

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy
11:27

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy

Published on: April 29, 2014

Pediatric renal cell carcinoma.

Justin E Sausville1, David J Hernandez, Pedram Argani

  • 1James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, 600 N. Wolfe St., Baltimore, MD 21287, USA. jsausville@smail.umaryland.edu

Journal of Pediatric Urology
|May 16, 2009
PubMed
Summary

Pediatric renal cell carcinoma (RCC) often presents as advanced disease and frequently involves MiT family translocations. Treatment parallels adult RCC, but chemotherapy effectiveness requires further study via multi-institutional protocols.

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Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

Published on: February 8, 2020

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Last Updated: Jun 23, 2026

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy
11:27

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy

Published on: April 29, 2014

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane
05:36

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

Published on: February 8, 2020

Area of Science:

  • Pediatric oncology
  • Nephrology
  • Cancer genetics

Background:

  • Renal cell carcinoma (RCC) accounts for approximately 5% of pediatric renal tumors.
  • It is recognized as a secondary malignancy in numerous cases.
  • Pediatric RCC typically presents with symptomatic, locally advanced disease, differing from adult presentations.

Purpose of the Study:

  • To review the current understanding of pediatric renal cell carcinoma.
  • To highlight key diagnostic and therapeutic considerations in this population.
  • To identify areas requiring further research, particularly in systemic therapy.

Main Methods:

  • Review of contemporary investigations into pediatric RCC.
  • Comparison of clinical presentation and surgical management with adult RCC.
  • Analysis of cytogenetic findings, specifically MiT family translocations.

Main Results:

  • A significant proportion of pediatric RCC tumors exhibit cytogenetic translocations involving the MiT family of transcription factors.
  • Surgical approaches for pediatric RCC are similar to adult cases, with ongoing discussion regarding lymph node dissection.
  • Limited data exists from adequately powered studies on the efficacy of adjuvant or neoadjuvant chemotherapy in pediatric RCC.

Conclusions:

  • Pediatric RCC is a distinct entity often presenting with advanced disease and specific genetic alterations.
  • Surgical management is standard, but optimal lymph node dissection strategies need clarification.
  • Further research, potentially through multi-institutional protocols, is crucial to establish the role of chemotherapy in treating pediatric RCC.