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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
The Functions of the Skeletal System01:22

The Functions of the Skeletal System

The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...
What is the Skeletal System?01:02

What is the Skeletal System?

Overview
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...

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Related Experiment Video

Updated: Jun 23, 2026

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

Bone loss in inflammatory disorders.

R Hardy1, M S Cooper

  • 1School of Clinical and Experimental Medicine, Institute of Biomedical Research, University of Birmingham, Birmingham, UK.

The Journal of Endocrinology
|May 16, 2009
PubMed
Summary
This summary is machine-generated.

Chronic inflammation causes bone loss by disrupting the bone remodeling cycle, leading to increased resorption and decreased formation. Therapies targeting these mechanisms may help treat inflammation-related bone loss.

Related Experiment Videos

Last Updated: Jun 23, 2026

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

Area of Science:

  • Bone biology
  • Inflammation
  • Metabolic diseases

Background:

  • Chronic inflammatory diseases are frequently linked to significant bone loss.
  • Bone loss in these conditions stems from multifactorial causes including inflammation, poor nutrition, reduced muscle mass, immobility, and treatments like glucocorticoids.

Purpose of the Study:

  • To review the complex interactions between inflammation and bone metabolism.
  • To discuss current and potential therapeutic strategies for managing inflammation-related bone loss.

Main Methods:

  • Literature review focusing on the mechanisms of inflammation-induced bone loss.
  • Analysis of the bone remodeling cycle in the context of chronic inflammation.

Main Results:

  • Inflammation directly impacts bone remodeling, often increasing bone resorption and decreasing bone formation.
  • This leads to an uncoupling of bone formation and resorption, favoring net bone loss.

Conclusions:

  • Understanding the interplay between inflammation and bone metabolism is crucial for developing effective treatments.
  • Therapeutic interventions targeting these pathways hold promise for mitigating bone loss in chronic inflammatory conditions.