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The Corneal Micropocket Assay: A Model of Angiogenesis in the Mouse Eye
11:49

The Corneal Micropocket Assay: A Model of Angiogenesis in the Mouse Eye

Published on: August 16, 2014

[In vitro and in vivo angiogenesis assays]

Takahisa Murata1

  • 1amurata@mail.ecc.u-tokyo.ac.jp

Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
|May 16, 2009
PubMed
Abstract

No abstract available in PubMed .

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Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...

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