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Related Experiment Video

Updated: Jun 23, 2026

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

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Published on: June 26, 2018

Multisystem failure due to three coexisting autoimmune diseases.

Arvind Pillai¹, Manish Gautam, Helen Williamson

¹Department of Haematology, Royal Liverpool University Hospital, Liverpool, UK.

Internal Medicine (Tokyo, Japan)

|May 16, 2009

Summary

Systemic lupus erythematosus (SLE) can present with rare autoimmune conditions like myelofibrosis and acquired hemophilia. Multidisciplinary care is crucial for managing these complex co-occurring diseases.

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Area of Science:

Rheumatology and Immunology
Hematology

Background:

Systemic lupus erythematosus (SLE) is a complex autoimmune disease with diverse clinical presentations.
SLE can co-occur with other autoimmune disorders, including myelofibrosis and acquired hemophilia, complicating diagnosis and management.

Observation:

A young woman presented with pancytopenia due to myelofibrosis and panserositis, initially presumed to be SLE.
The patient required intensive care for respiratory and renal complications.
Bleeding complications arose due to acquired hemophilia, necessitating specialized intervention.

Findings:

Prompt diagnosis and multidisciplinary management were essential for stabilizing the patient's critical condition.
Treatment for presumed SLE improved her autoimmune status, but acquired hemophilia presented a life-threatening challenge.
Integrated care successfully resolved complications and stabilized the patient's multiple autoimmune conditions.

Implications:

This case highlights rare presentations of SLE and the diagnostic and therapeutic challenges of co-existing autoimmune diseases.
Physicians should be aware of the potential for concurrent myelofibrosis and acquired hemophilia in SLE patients.
Emphasizes the critical role of multidisciplinary collaboration in managing complex, multi-system autoimmune disorders.