Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Hormones and Bone Tissue

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...

Bone Disorders

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

Essential Minerals for Bone Health

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...

Functions of Thyroid Hormones

Functions of Thyroid Hormones

The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...

What is the Skeletal System?

What is the Skeletal System?

Skeleton and Calcium Homeostasis

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Associations of testosterone, sex hormone-binding globulin, and related hormones with risks of cancer death, incident cancer, and incident prostate cancer in men: individual participant data meta-analyses.

The lancet. Healthy longevity·2026

Same author

Natural history of thyroid function in ageing: an individual participant data analysis of 137 488 participants from 31 prospective cohort studies.

The lancet. Diabetes & endocrinology·2026

Same author

The effects of marine fatty acid omega-3 supplements on incident fractures and bone mineral density in generally healthy adults.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026

Same author

Response to Letter to the Editor regarding "The relationship between treatment-related changes in total hip BMD measured after 12, 18, and 24 mo and fracture risk reduction in osteoporosis clinical trials: the FNIH-ASBMR-SABRE project".

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026

Same author

Association Between Hyponatremia and Mortality and Readmission in Multimorbid Older Adults-A Cohort Study.

Journal of clinical medicine·2025

Same author

Screening for Osteoporosis in Older Men-Getting Closer to Yes.

JAMA internal medicine·2025

Search research articles

Related Experiment Video

Updated: Jun 23, 2026

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

Bone: Does TSH concentration influence skeletal health?

Douglas C Bauer

Nature Reviews. Endocrinology

|May 16, 2009

Summary

Variations in serum thyroid-stimulating hormone (TSH) concentration within the normal range do not significantly impact bone mineral density (BMD). This finding addresses the ongoing debate regarding thyroid function and skeletal health.

Area of Science:

Endocrinology
Bone Metabolism
Public Health

Background:

Altered thyroid function is debated for its skeletal consequences.
Previous research has suggested potential links between thyroid hormones and bone mineral density (BMD).

Discussion:

This study investigates the relationship between serum TSH concentration and BMD using data from the Tromsø population survey.
The analysis focuses on variations within the normal reference range for TSH.

Key Insights:

Serum TSH variations within the normal range show minimal influence on BMD.
These findings suggest that euthyroid individuals with normal TSH levels are unlikely to experience significant skeletal changes due to thyroid status.

Outlook:

Related Experiment Videos

Last Updated: Jun 23, 2026

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

Further research could explore the impact of subclinical thyroid dysfunction on BMD.
Longitudinal studies may provide deeper insights into the long-term effects of thyroid hormone variations on bone health.