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Updated: Jun 23, 2026
08:21
A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
Published on: October 26, 2020
[Renal artery stenosis. Pathophysiology--diagnosis--therapy]
Heinrich Wieneke1, Thomas Friedrich Michael Konorza, Holger Eggebrecht
1Klinik für Kardiologie, Westdeutsches Herzzentrum, Universitätsklinikum Essen, Essen, Germany. heinrich.wieneke@uni-essen.de
Medizinische Klinik (Munich, Germany : 1983)
|May 16, 2009
Summary
Renal artery stenosis (RAS) is common in older adults. Careful diagnosis is crucial before intervention, as not all patients benefit from revascularization, and procedures carry risks.
Area of Science:
- Cardiovascular Medicine
- Nephrology
- Interventional Radiology
Context:
- Renal artery stenosis (RAS) is a prevalent and progressive condition, particularly in patients over 65, with reported frequencies of 11-23% in those undergoing coronary angiography.
- Despite its prevalence, the benefits of renal artery revascularization for reducing cardiovascular and renal events remain debated, with up to 40% of patients not experiencing positive outcomes.
Purpose:
- To emphasize the necessity of comprehensive diagnostic work-ups for renal artery stenosis (RAS) prior to intervention.
- To highlight the importance of integrating both morphological and functional tests for accurate patient selection.
Summary:
- Morphological evaluation can be performed using multislice computed tomography, magnetic resonance tomography, or digital subtraction angiography.
- Functional assessment, crucial for determining physiological significance, can be achieved through Doppler ultrasound or invasive pressure and flow measurements.
- The long-term predictive value of these diagnostic methods requires further assessment.
Impact:
- Percutaneous intervention for RAS, while less risky than surgery, carries risks of renal function deterioration and procedure-dependent complications due to contrast media.
- A thorough consideration of the pros and cons of renal artery revascularization is mandatory for optimal patient management.
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