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04:39
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
Autoimmune hypothyroidism and lupus-like syndrome
Garip Sahin1, Cengiz Korkmaz, Serap Işiksoy
1Division of Nephrology, Department of Internal Medicine, Eskişehir Osmangazi University, Eskisehir, Turkey.
Rheumatology International
|May 16, 2009
Summary
Hashimoto's thyroiditis and other thyroid disorders are common in connective tissue diseases. Autoimmune hypothyroidism can mimic systemic lupus erythematosus symptoms, including kidney and joint issues.
Area of Science:
- Endocrinology
- Rheumatology
- Nephrology
Background:
- Connective tissue diseases (CTDs) and thyroid disorders, especially Hashimoto's thyroiditis, frequently coexist.
- Hypothyroidism and CTDs share overlapping symptoms like myalgia, arthralgia, and stiffness.
- Autoimmune hypothyroidism (AIH) can present with systemic manifestations mimicking CTDs.
Observation:
- A case of AIH is presented with significant proteinuria, hematuria, pleural effusion, and arthritis.
- These clinical features closely simulated systemic lupus erythematosus (SLE).
Findings:
- The patient's presentation highlights the potential for AIH to manifest with multi-system involvement.
- Renal, cutaneous, and cardiovascular symptoms in AIH can be mistaken for CTD, specifically SLE.
Implications:
- Increased awareness of AIH is crucial for accurate diagnosis in patients with suspected CTDs.
- Distinguishing AIH from CTDs like SLE is essential for appropriate management and treatment strategies.
- This case underscores the importance of considering thyroid function in the workup of patients with autoimmune conditions.
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