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Related Experiment Video

Updated: Jun 23, 2026

Human Circadian Phenotyping and Diurnal Performance Testing in the Real World

Human Circadian Phenotyping and Diurnal Performance Testing in the Real World

Published on: April 7, 2020

Chronotype and body composition in bipolar disorder.

Isabella Soreca¹, Andrea Fagiolini, Ellen Frank

¹Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania, USA. sorecai@upmc.edu

Chronobiology International

|May 16, 2009

Summary

Obesity in bipolar disorder patients is linked to their chronotype. Evening chronotype individuals showed higher body fat percentages, suggesting a potential factor in obesity within this population.

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Last Updated: Jun 23, 2026

Human Circadian Phenotyping and Diurnal Performance Testing in the Real World

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Published on: April 7, 2020

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

Area of Science:

Psychiatry
Chronobiology
Metabolic Health

Background:

Bipolar disorder is frequently associated with obesity and metabolic disturbances.
The relationship between circadian rhythms and metabolic health in psychiatric disorders is an area of growing interest.

Purpose of the Study:

To investigate the association between chronotype and body fat percentage in patients with bipolar I disorder.
To determine if chronotype independently predicts body fat in this population.

Main Methods:

Cross-sectional study of 29 adult patients with bipolar I disorder (euthymic).
Assessment of total body fat, mood symptoms, sleep quality, and self-reported chronotype.
Statistical analysis to determine the variance in body fat explained by chronotype, controlling for covariates.

Main Results:

Chronotype accounted for 19% of the variance in total body fat.
Individuals with an evening chronotype exhibited a higher percentage of total body fat.
This association remained significant after adjusting for age, sex, mood state, and sleep quality.

Conclusions:

Evening chronotype is associated with increased body fat in bipolar disorder patients.
Chronotype may serve as a potential biomarker or proxy for underlying factors contributing to obesity in bipolar disorder.
Further research is warranted to elucidate the specific mechanisms linking chronotype and obesity in this clinical population.